Pancragen 20mg-Synthetic Tetrapeptide Bioregulator for Pancreatic Function Research

Pancragen 20mg-Synthetic Tetrapeptide Bioregulator for Pancreatic Function Research

Pancragen 20mg (Bioregulator) Introduction

Pancragen is a synthetic tetrapeptide bioregulator, also known as a Khavinson peptide, designed to support and restore pancreatic function. Composed of the amino acid sequence Lys-Glu-Asp-Trp (KEDW), it was originally derived from peptides isolated in bovine pancreatic cells and acts primarily by interacting with nuclear components like histones and DNA to influence gene expression, cell differentiation, and epigenetic regulation in pancreatic tissues. Research focuses on its potential to normalize endocrine activity, improve glucose metabolism, enhance insulin production, and mitigate age-related or diabetes-induced pancreatic decline. Supplied as a 20mg vial of lyophilized powder for laboratory use, Pancragen is not approved for human consumption and is intended solely for in vitro research.

Chemical and Physical Properties

Research Applications

• Blood Sugar and Diabetes Management: In animal models of diabetes and hyperinsulinemia, Pancragen normalizes insulin and C-peptide levels, reduces fasting glucose, lowers insulin resistance, and improves glucose tolerance without the side effects seen in some pharmaceuticals (e.g., unlike glimepiride). It enhances β-cell insulin production while suppressing α-cell glucagon secretion, restoring pancreatic morphology and function even after treatment cessation.
• Metabolic Syndrome and Aging: By regulating melatonin secretion through insulin-glucagon feedback loops, it reduces the incidence and severity of metabolic syndrome in aging models. It upregulates pancreatic differentiation factors (e.g., Ptf1a, Pdx1, Pax6) and proliferation markers (e.g., PCNA, Ki67), while decreasing pro-apoptotic proteins like p53 and aging biomarkers such as caspase-3 and cathepsin B.
• Pancreatic Cell Protection and Proliferation: Stimulates growth and differentiation of acinar and islet cells, increases expression of matrix metalloproteinases (MMP2, MMP9), serotonin, and anti-apoptotic Mcl1, promoting overall endocrine function in elderly or stressed pancreatic tissues.
• Vascular and Endothelial Health: Protects mesenteric capillaries from hyperglycemia-induced damage by normalizing endothelial adhesion, potentially preventing diabetes complications like cardiovascular disease or nephropathy.
• Other Potential Uses: Modulates inflammation (e.g., reduces TNF-α, increases IGF-1) and oxidative stress; preliminary studies suggest benefits in early metabolic dysfunction and anti-aging therapies for the endocrine system.

Handling and Storage

• Strictly for laboratory research purposes; prohibited for human or animal use, ingestion, or medical treatment.
•  Store lyophilized powder refrigerated (2-8°C) to maintain stability; reconstitute with bacteriostatic water for experiments.
• Purity typically >99% via HPLC; handled by qualified professionals only, assuming all risks of use.

Research Applications

Both peptides show promise in preclinical models for age-related diseases, but their applications diverge:

Similarities

• Bioregulator Class: Both are short-chain peptides that influence DNA-histone interactions for epigenetic rejuvenation, with high specificity and low toxicity in research settings.
• Anti-Aging Overlap: They reduce cellular senescence and apoptosis, upregulate growth factors, and show enhanced efficacy in older subjects.
• Administration and Safety: Research-grade only; reconstituted in bacteriostatic water, stored refrigerated (2-8°C). No reported genotoxicity; purity >99% via HPLC.
• Limitations: Preclinical data dominate; human trials are sparse or absent. Not for therapeutic use.

Differences

• Scope: Pancragen is narrowly endocrine-focused (pancreas/metabolism), ideal for diabetes models, while Epitalon offers broader longevity benefits via telomerase, suiting general anti-aging research.
• Molecular Profile: Pancragen's tryptophan inclusion may enhance bioavailability or receptor binding, contributing to its metabolic modulation; Epitalon's simpler glycine terminus supports telomerase docking.
• Potency in Models: Pancragen excels in restoring organ morphology (e.g., islet cells), whereas Epitalon demonstrates quantifiable telomere extension (up to 33% in some studies).

For lab procurement, consult peptide suppliers for batch-specific data. While synergistic use in multi-peptide protocols is explored in research, consult protocols carefully.

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FAQ
 
Q1: Can I get some samples?
 
A: Yes, we can provide samples. However, customers must bear the shipping cost.
 
 
Q2: How to pay?
 
A: We accept various payment methods, including T/T and other options.
 
 
Q 3: What is your MOQ (Minimum Order Quantity)?
 
A: Our standard MOQ is 5kits. However, smaller quantities, such as 100 grams, can be arranged for a corresponding sample fee.
 
 
Q 4: What is the shipping time?
 
A: Orders are usually shipped within 3-7 days with a tracking number. Delivery times vary by destination. Please get in touch with us for details.